Gruissem, Wilhelm, Prof.

EDUCATION

University of Bonn, Germany, M.S. 1977 (Biological Sciences)
University of Bonn, Germany, Ph.D. 1979 (Genetics and Molecular Biology)

PROFESSIONAL EXPERIENCE

Research Associate, University of Marburg, Marburg, Germany, 1979-1980
Research Associate, University of Colorado, Boulder, 1981-1983
Assistant/Associate Professor, University of California, Berkeley, 1984-1990
Professor of Plant Biology, University of California, Berkeley, 1990-2000
Chair, Department of Plant and Microbial Biology, Univ. of California, Berkeley, 1993-1998
Director, PMB–Novartis Collaborative Research Program, 1998-2000
Professor of Plant Biotechnology, ETH Zurich, 2000-present
Co-Director, Functional Genomics Center Zurich, 2001-present
Chair, Institute of Plant Sciences, ETH Zurich, 2004-2005
Chair, Zurich-Basel Plant Science Center, 2004-2006
President, European Plant Science Organization, 2006-2010
Guest Professor, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 2008-present
Chair, Department of Biology, ETH Zurich, 2009-2011

FELLOWSHIPS/HONORS

Hoerlein Predoctoral Fellowship, University of Bonn, West-Germany, 1976
DAAD Fellowship, University of Cape Town, South Africa, 1977
University of Bonn, West-Germany, Predoctoral Fellowship, 1977-1978
Deutsche Forschungsgemeinschaft, Postdoctoral Fellowship, Univ. Colorado, 1981-1982
Max-Kade Foundation, New York, Postdoctoral Fellow, Univ. of Colorado, Boulder, 1983.
Chair, Gordon Conference, Italy 1994, California 2007
UC Berkeley Chancellor's Research Initiative Award, 1996
Fellow, American Association for the Advancement of Sciences, 1998
Chancellor’s Professorship, UC Berkeley, 1999
Four awards for the textbook “Biochemistry and Molecular Biology of Plants” (published in 2000; translated into five languages, including Italian, Chinese and Japanese)
Anniversary Prize 2003 of the Eiselen Foundation Ulm, Germany
Fellow and Corresponding Member, American Society of Plant Biologists, 2007

SELECTED PROFESSIONAL ACTIVITIES

Panel Member, USDA 1988, DOE 1988, 1992, NSF 1990, 1996, 2007, NIH 1998, ERC 2008-present
Consultant, Shell Development, Monsanto, GeneSoft, CropDesign, UNIDO
Instructor, Cold Spring Harbor Laboratory Course on Plant Development, 1989-1991
Advisory Boards, RIKEN (Japan), Yale-Peking Inst for Agribiotechnology, Plant Systems Biology Gent, Syngenta, Swiss Institute for Bioinformatics, Gregor-Mendel-Institute Vienna, GABI-Future, Biotechnology Advisor for the Premier of the Republic of China (Taiwan)
Editorial Boards, Plant Molecular Biology 1988-1994, Experimental Biology Online, 1996-1999, BioProtocol, 2000-2004, Nucleic Acids Research, 1991-present, Trends in Plant Sciences 2009-present, Annual Review of Plant Biology, 2009-present
Co-Editor and Associate Editor, The Plant Cell, 1990-1995
Feature Editor, Plant Physiology, 2000-2002
Editor-in-Chief, Plant Molecular Biology, 2001-present
Advisory Board, Molecular Plant, 2006-present

SUMMARY OF RESEARCH INTERESTS

My laboratory is currently working on four major research projects:

• Proteome analysis and bioinformatics tool development
• Systems biology of development and metabolic regulation
• Coordination of cell cycle control and differentiation
• Biotechnology of cassava, rice and wheat

PUBLICATIONS

• Vanderschuren, H., Boycheva, S., Li, K-T, Szydlowski, N., Gruissem, W., Fitzpatrick, T.B. (2013)
  Strategies for vitamin B6 biofortification of plants: A dual role as a micronutrient and a stress protectant
  Frontiers in Plant Science, 4, 143, 1-7    [Link]
   
• Chetty CC, Rossin CB, Gruissem W, Vanderschuren H, Rey ME. (2013)
  Empowering biotechnology in southern Africa: establishment of a robust transformation platform for the production of transgenic industry-preferred cassava
  New Biotechnology, 2, 30, 136-143    [Link]
   
• Vanderschuren H, Moreno I, Anjanappa RB, Zainuddin IM, Gruissem W (2012)
  Exploiting the Combination of Natural and Genetically Engineered Resistance to Cassava Mosaic and Cassava Brown Streak Viruses Impacting Cassava Production in Africa
  PLoS One, Vol 7 (9), e45277    [Link]
   
• Baerenfaller K, Massonnet C, Walsh S, Baginsky S, Bühlmann P, Hennig L, Hirsch-Hoffmann M, Howell KA, Kahlau S, Radziejwoski A, Russenberger D, Rutishauser D, Small I, Stekhoven D, Sulpice R, Svozil J, Wuyts N, Stitt M, Hilson P, Granier C and Gruissem W (2012)
  Systems-based analysis of Arabidopsis leaf growth reveals adaptation to water deficit
  Molecular Systems Biology    [Link]
   
• Beleut M, Zimmermann P, Baudis M, Bruni N, Bühlmann P, Laule O, Luu VD, Gruissem W, Schraml P, Moch H. (2012)
  Integrative genome-wide expression profiling identifies three distinct molecular subgroups of renal cell carcinoma with different patient outcome.
  BMC Cancer, 12:310    [Link]
   
• Zainuddin I, Schlegel K, Gruissem W, Vanderschuren H. (2012)
  Robust transformation procedure for the production of transgenic farmer-preferred cassava landraces
  Plants Methods, 8, 24    [Link]
   
• Bart R, Cohn M, Kassen A, McCallum EJ, Shybut M, Petriello A, Krasileva K, Dahlbeck D, Medina C, Alicai T, Kumar L, Moreira LM, Neto JR, Verdier V, Santana MA, Kositcharoenkul N, Vanderschuren H, Gruissem W, Bernal A, Staskawicz BJ (2012)
  High-throughput genomic sequencing of cassava bacterial blight strains identifies conserved effectors to target for durable resistance
  Proc Natl Acad Sci U S A    [Link]
   
• Hirsch-Hoffmann M, Gruissem W and Baerenfaller K (2012)
  pep2pro: the high-throughput proteomics data processing, analysis, and visualization tool
  Frontiers in Plant Proteomics    [Link]
   
• Müller M, Patrignani A, Rehrauer H, Gruissem W, Hennig L. (2012)
  Evaluation of alternative RNA labeling protocols for transcript profiling with Arabidopsis AGRONOMICS1 tiling arrays.
  Plant Methods, 8:18    [Link]
   
• Gutzat R, Borghi L, Gruissem W. (2012)
  Emerging roles of RETINOBLASTOMA-RELATED proteins in evolution and plant development
  Trends Plant Science, 3, 17, 139-148    [Link]
   
• Vranová E, Coman D, Gruissem W. (2012)
  Structure and dynamics of the isoprenoid pathway network.
  Oxford Journals, Mol Plant, 2, 5, 318-3    [Link]
   
• Niklaus, M., Gruissem, W., Vanderschuren, H. (2011)
  Efficient transformation and regeneration of transgenic cassava using the neomycin phosphotransferase gene as aminoglycoside resistance marker gene
  GM Crops, 2, 3, 193-200    [Link]
   
• Bischof S, Baerenfaller K, Wildhaber T, Troesch R, Vidi P-A, Roschitzki B, Hirsch-Hoffmann M, Hennig L, Kessler F, Gruissem W and Baginsky S (2011)
  Plastid Proteome Assembly without Toc159: Photosynthetic Protein Import and Accumulation of N-Acetylated Plastid Precursor Proteins
  The Plant Cell    [Link]
   
• Ectopic Gene Expression and Organogenesis in Arabidopsis Mutants Missing BRU1 Required for Genome Maintenance Yusuke Ohno, Jarunya Narangajavana, Akiko Yamamoto, Tsukaho Hattori, Yasuaki Kagaya, Jerzy Paszkowski, Wilhelm Gruissem, Lars Hennig, Shin Takeda* (2011)
  Ectopic Gene Expression and Organogenesis in Arabidopsis Mutants Missing BRU1 Required for Genome Maintenance
  Genetics, 189, 83-95    [Link]
   
• Gutzat R, Borghi L, Fütterer J, Bischof S, Laizet Y, Hennig L, Feil R, Lunn J, Gruissem W. (2011)
  RETINOBLASTOMA-RELATED PROTEIN controls the transition to autotrophic plant development.
  Development, 14, 138, 2977-2986    [Link]
   
• Moreno, I., Gruissem, W., Vanderschuren, H. (2011)
  Reference genes for reliable potyvirus quantitation in cassava and analysis of Cassava brown streak virus load in host varieties
  Journal of Virological Methods, 177, 49-54    [Link]
   
• Reiland S, Finazzi G, Endler A, Willig A, Baerenfaller K, Grossmann J, Gerrits B, Rutishauser D, Gruissem W, Rochaix JD, Baginsky S (2011)
  Comparative phosphoproteome profiling reveals a function of the STN8 kinase in fine-tuning of cyclic electron flow (CEF).
  PNAS    [Link]
   
• Sayre, R., Beeching, J. R., Cahoon, E. B., Egesi, C., Fauquet, C., Fellman, J., Fregene, M., Gruissem, W., Mallowa, S., Manary, M., Maziya-Dixon, B., Mbanaso, A., Schachtman, D. P., Siritunga, D., Taylor, N., Vanderschuren, H., Zhang, P. (2011)
  The BioCassava Plus Program: Biofortification of Cassava for Sub-Saharan Africa.
  Annu Rev Plant Biol, 62, 251-272    [Link]
   
• Vranová E, Hirsch-Hoffmann M., Gruissem W. (2011)
  AtIPD: A Curated Database of Arabidopsis Isoprenoid Pathway Models and Genes for Isoprenoid Network Analysis
  Plant Physiology    [Link]
   
• Owiti, J., Grossmann, J., Gehrig, P., Dessimoz, C., Laloi, C., Hansen, M.B., Gruissem, W., Vanderschuren, H. (2011)
  iTRAQ-based analysis of changes in the cassava root proteome reveals pathways associated with post-harvest physiological deterioration.
  The Plant Journal, 67, 145-156    [Link]
   
• Reiland S, Grossmann J, Baerenfaller K, Gehrig P, Nunes-Nesi A, Fernie AR, Gruissem W and Baginsky S (2011)
  Integrated proteome and metabolite analysis of the de-etiolation process in plastids from rice (Oryza sativa L.).
  Proteomics    [Link]
   
• Baerenfaller K, Hirsch-Hoffmann M, Svozil J, Hull R, Russenberger D, Bischof S, Lu Q, Gruissem W, Baginsky S (2011)
  pep2pro: a new tool for comprehensive proteome data analysis to reveal information about organ-specific proteomes in Arabidopsis thaliana.
  Integrative Biology    [Link]
   
• Bull, S.E., Ndunguru, J., Gruissem, W., Beeching, J.R., Vanderschuren, H. (2011)
  Cassava: constraints to production and the transfer of biotechnology to African laboratories
  Plant Cell Reports, 5, 30, 779-787    [Link]
   
• Joshi HJ, Hirsch-Hoffmann M, Baerenfaller K, Gruissem W, Baginsky S, Schmidt R, Schulze WX, Sun Q, van Wijk KJ, Egelhofer V, Wienkoop S, Weckwerth W, Bruley C, Rolland N, Toyoda T, Nakagami H, Jones AM, Briggs SP, Castleden I, Tanz SK, Millar AH, Heazlewood JL. (2011)
  MASCP Gator: An aggregation portal for the visualization of Arabidopsis proteomics data.
  Plant Physiology    [Link]
   
• Borghi, L., Gutzat, R., Fütterer, J., Laizet, Y., Hennig, L., and Gruissem, W. (2010)
  Arabidopsis RETINOBLASTOMA-RELATED (RBR) is required for stem cell maintenance, cell differentiation and lateral organ production.
  Plant Cell    [Link]
   
• Massonnet C, Vile D, Fabre J, Hannah MA, Caldana C, Lisec J, Beemster GT, Meyer RC, Messerli G, Gronlund JT, Perkovic J, Wigmore E, May S, Bevan MW, Meyer C, Rubio-Díaz S, Weigel D, Micol JL, Buchanan-Wollaston V, Fiorani F, Walsh S, Rinn B, Gruissem W, Hilson P, Hennig L, Willmitzer L, Granier C. (2010)
  Probing the reproducibility of leaf growth and molecular phenotypes: a comparison of three Arabidopsis accessions cultivated in ten laboratories
  Plant Physiol., 152, 4, 2142-57    [Link]
   
• Baginsky, S., Hennig, L., Zimmermann, P., Gruissem, W. (2010)
  Gene expression analysis, proteomics, and network discovery.
  Plant Physiol, 152, 402-410    [Link]
   
• Rehrauer, H., Aquino, C., Gruissem, W., Henz, S.R., Hilson, P., Laubinger, S., Naouar, N., Patrignani, A., Rombauts, S., Shu, H., Van de, P.e.Y., Vuylsteke, M., Weigel, D., Zeller, G., Hennig, L. (2010)
  AGRONOMICS1: A new resource for Arabidopsis transcriptome profiling.
  Plant Physiol, 152, 487-499    [Link]
   
• Bull S E, Owiti J A, Niklaus M, Beeching J R, Gruissem W & Vanderschuren H. (2009)
  Agrobacterium-mediated transformation of friable embryogenic calli and regeneration of transgenic cassava
  Nature Protocols, 4, 1845 - 1854    [Link]
   
• Vanderschuren H, Alder A, Zhang P, Gruissem W. (2009)
  Dose-dependent RNAi-mediated geminivirus resistance in the tropical root crop cassava.
  Plant Molecular Biology , 70, (3), 265-272    [Link]
   
• Exner, V., Aichinger, E., Shu, H., Wildhaber, T., Alfarano, P., Caflisch, A., Gruissem, W., Köhler, C., Hennig, L. (2009)
  The chromodomain of LIKE HETEROCHROMATIN PROTEIN 1 is essential for H3K27me3 binding and function during Arabidopsis development.
  PLoS One, 4, e5335    [Link]
   
• Reiland S, Messerli G, Baerenfaller K, Gerrits B, Endler A, Grossmann J, Gruissem W and Baginsky S (2009)
  Large-scale Arabidopsis phosphoproteome profiling reveals novel chloroplast kinase substrates and phosphorylation networks
  Plant Physiology    [Link]
   
• Alexandre, C., Möller-Steinbach, Y., Schönrock, N., Gruissem, W., Hennig, L. (2009)
  Arabidopsis MSI1 is required for negative regulation of the response to drought stress.
  Mol Plant, 2, 675 - 687    [Link]
   
• Baerenfaller K, Grossmann J, Grobei MA, Hull R, Hirsch-Hoffmann M, Yalovsky S, Zimmermann P, Grossniklaus U, Gruissem W and Baginsky S (2008)
  Genome-Scale Proteomics Reveals Arabidopsis thaliana Gene Models and Proteome Dynamics
  Science, 320(5878), 938-41
   
• Exner, V.; Gruissem, W.; Hennig, L. (2008)
  Control of trichome branching by Chromatin Assembly Factor-1
  BMC Plant Biol, 8, 54    [Link]
   
• Baerenfaller K, Gruissem W and Baginsky S (2008)
  Sample Preparation and Data Processing in Plant Proteomics
  Proteomics Sample Preparation, Wiley-VCH Verlag
   
• Exner, V., Hirsch-Hoffmann, M., Gruissem, W., Hennig, L. (2008)
  PlantDB - a versatile database for managing plant research
  Plant Meth, 4, 1    [Link]
   
• Grossmann J, Fischer B, Baerenfaller K, Owiti J, Buhmann JM, Gruissem W, Baginsky S. (2007)
  A workflow to increase the detection rate of proteins from unsequenced organisms in high-throughput proteomics experiments.
  Proteomics, 7(23), 4245-54
   
• Wille, A., Gruissem, W., Bühlmann, P., Hennig, L. (2007)
  EVE - External Variance Estimation increases statistical power for detecting differentially expressed genes
  Plant Journal, 52, 561-569    [Link]
   
• Vanderschuren H, Akbergenov R, Pooggin M, Hohn T, Gruissem W and Zhang P (2007)
  Transgenic cassava resistance to African cassava mosaic virus is enhanced by viral DNA-A bidirectional promoter-derived siRNAs.
  Plant Molecular Biology, 64, 549-557    [Link]
   
• Vanderschuren H, Stupak M, Fütterer J, Gruissem W and Zhang P (2007)
  Engineering resistance to geminiviruses - Review and perspectives.
  Plant Biotechnology Journal, 5, 207-220    [Link]
   
• Kleffmann, T., Zychlinski, A., Russenberger, D., Hirsch-Hoffmann, M., Gehrig, P., Gruissem, W. and Baginsky, S. (2007)
  Proteome dynamics during plastid differentiation in rice (Oryza sativa L.)
  Plant Physiology, 143, 912-923    [Link]
   
• Siddique, A., Grossmann, J., Gruissem, W. and Baginsky, S. (2007)
  Proteome analysis of bell pepper (Capsicum annum L.) chromoplasts
  Plant &Cell Physiology, in press
   
• Vivien Exner, Patti Taranto, Nicole Schönrock, Wilhelm Gruissem and Lars Hennig (2006)
  Chromatin assembly factor CAF-1 is required for cellular differentiation during plant development
  Development, 133, 4163-4172    [Link]
   
• Stupak M, Vanderschuren H, Gruissem W and Zhang P (2006)
  Biotechnological approaches to cassava protein improvement.
  Trends in Food Science and Technology, 17, 634-641    [Link]
   
• Schönrock N, Bouveret R, Leroy O, Borghi L, Köhler C, Gruissem W, Hennig L (2006)
  Polycomb-group proteins repress the floral activator AGL19 in the FLC-independent vernalization pathway
  Genes & Development, 12, 20, 1667-1678    [Link]
   
• Bouveret, R., Schönrock, N., Gruissem, W., Hennig, L. (2006)
  Regulation of flowering time by Arabidopsis MSI1.
  Development, 133, 1693-1702    [Link]
   
• Prelic A, Bleuler S, Zimmermann P, Wille A, Bühlmann P, Gruissem W, Hennig L, Thiele L, Zitzler E (2006)
  A systematic comparison and evaluation of biclustering methods for gene expression data
  Bioinformatics, 22, 1122-1129    [Link]
   
• Sautter C, Poletti S, Zhang P and Gruissem W (2006)
  Biofortification of essential nutritional compounds and trace elements in rice and cassava
  Proceedings of the Nutrition Society, 65, 153-159    [Link]
   
• Schönrock, N., Exner, V., Gruissem, W., and Hennig, L. (2006)
  Functional genomic analysis of CAF-1 mutants in Arabidopsis thaliana.
  J Biol Chem, 281, 9560-9568    [Link]
   
• Akbergenov R, Si-Ammour A, Blevins T, Amin I, Kutter C, Vanderschuren H, Zhang P, Gruissem W, Meins F Jr, Hohn T and Pooggin MM (2006)
  Molecular characterization of geminivirus-derived small RNAs in different plant species.
  Nucleic Acids Research, 34(2), 462-471    [Link]
   
• Zimmermann P, Schildknecht B, Garcia-Hernandez M, Gruissem W, Craigon D, Mukherjee G, May S, Parkinson H, Rhee S, Wagner U and L Hennig (2006)
  MIAME/Plant - adding value to plant microarrray experiments
  Plant Methods, 2, 1    [Link]
   
• Laule O, Hirsch-Hoffmann M, Hruz T, Gruissem W, and P Zimmermann (2006)
  Web-based analysis of the mouse transcriptome using Genevestigator
  BMC Bioinformatics, 7:311    [Link]
   
• Tomas Hruz, Matthias Hirsch-Hoffmann, Wilhelm Gruissem, Philip Zimmermann (2006)
  Reducing Java internet project risks: a case study of public measurement of client component functionality in the user community
  Proceedings of the 4th international symposium on Principles and practice of programming in Java, ACM International Co, 178
   
• Baginsky, S. and Gruissem, W. (2006)
  Arabidopsis thaliana proteomics-from proteome to genome
  J. Exp. Botany., 57, 1485-91
   
• Fischer B, Grossmann J, Roth V, Gruissem W, Baginsky S, Buhmann JM (2006)
  Semi-supervised LC/MS alignment for differential proteomics
  Bioinformatics, 22, e132-40
   
• Kleffmann, T., Hirsch-Hoffmann, M., Gruissem, W. and Baginsky, S. (2006)
  plprot-a comprehensive proteome database for different plastid types
  Plant Cell Physiol, 47, 3, 432-436    [Link]
   
• Nesvizhskii, A., Roos, F.F., Grossmann, J., Vogelzang, M., Eddes, J.S., Gruissem, W., Baginsky, S. and Aebersold, R. (2006)
  Dynamic Spectrum Quality Assessment and Iterative Computational Analysis of Shotgun Proteomic Data: Toward More Efficient Identification of Post-translational Modifications, Sequence Polymorphisms, and Novel Peptides.
  Molecular and Cellular Proteomics, 5, 652-70
   
• Sautter C, Poletti S, Zhang P und Gruissem W (2006)
  Anreicherung von essenziellen Nahrungs- und Spurenelementen in Nutzpflanzen am Beispiel von Reis und Maniok.
  Zell- und Molekularbiologie in der Inneren Medizin, 59-66    [Link]
   
• Siddique, M.A., Gruissem, W. and Baginsky, S. (2006)
  Proteomics of Tobacco Bright Yellow-2 (BY-2) Cell Culture Plastids
  Tobacco BY-2 cells: A new treatise, 313-326
   
• Klaas Vandepoele, Kobe Vlieghe, Kobe Florquin, Lars Hennig, Gerrit T.S. Beemster, Wilhelm Gruissem, Yves Van de Peer, Dirk Inze, and Lieven De Veylder (2005)
  Genome-Wide Identification of Potential Plant E2F Target Genes
  Plant Physiology, 1, 139, 316-328    [Link]
   
• Zhang P, Vanderschuren H, Fütterer J and Gruissem W (2005)
  Resistance to cassava mosaic disease in transgenic cassava expressing antisense RNAs targeting virus replication genes.
  Plant Biotechnology Journal, 3, 385-397    [Link]
   
• Baginsky, S., Kleffmann, T., von Zychlinski, A. and Gruissem, W. (2005)
  Analysis of shotgun proteomics and RNA profiling data from Arabidopsis thaliana chloroplasts
  Journal of Proteome Research, 4, 637-640
   
• Beemster, G.T., De Veylder, L., Vercruysse, S., West, G., Rombaut, D., Van Hummelen, P., Galichet, A., Gruissem, W. and Inze, D. (2005)
  Genome-wide analysis of gene expression profiles associated with cell cycle transitions in growing organs of Arabidopsis.
  Plant Physiology, in press
   
• Fischer, B., Roth, V., Roos, F., Grossmann, J., Baginsky, S., Widmayer, P., Gruissem, W. and Buhmann, J.M. (2005)
  NovoHMM - a hidden Markov Model for de Novo Peptide Sequencing
  Analytical Chemistry, 77, 7265-7273
   
• Grossmann J., Roos F.F., Cieliebak M., Jakob R., Liptak Z., Mathis L.K., Muller M., Widmayer P., Gruissem W. and Baginsky S. (2005)
  AUDENS: a tool for automated peptide de novo sequencing
  Journal of Proteome Research, 10, 1768-1774
   
• Hennig, L., Bouveret, R. and Gruissem, W. (2005)
  MSI-like proteins - an escort service for chromatin assembly and remodeling complexes.
  Trends in Cell Biolgoy, 15, 295-302    [Link]
   
• Jelesko, J.G., Carter, K., Kinoshita, Y. and Gruissem, W. (2005)
  Frequency and character of alternative somatic recombination fates during T-DNA integrations.
  Molecular Genetics and Genomics, in press
   
• Menges, M., de Jager, S.M., Gruissem, W. and Murray, J.A.H. (2005)
  Global analysis of the core cell cycle regulators of Arabidopsis identifies novel genes, reveals multiple and highly specific profiles of expression and provides a coherent model for cell cycle control.
  Plant Journal, 41, 546-566
   
• von Zychlinski, A., Kleffmann, T., Krishnamurthy, N., Sjölander, K., Baginsky, S. and Gruissem, W. (2005)
  Proteome analysis of the rice etioplast: metabolic and regulatory networks and novel protein functions
  Molecular and cellular Proteomics, 4, 1072-1084
   
• Zimmermann, P., Hennig, L. and Gruissem, W. (2005)
  Gene expression analysis and network discovery using Genevestigator.
  Trends in Plant Science, 9, 10, 407-409    [Link]
   
• Bellaoui M and Gruissem W. (2004)
  Altered expression of the Arabidopsis ortholog of DCL affects normal plant development.
  Planta, 219, 819-826    [Link]
   
• Wille A, Zimmermann P, Vranová E, Bleuler S, Fürholz A, Hennig L, Laule O, Prelíc A, von Rohr P, Thiele L, Zitzler E, Gruissem W, Bühlmann P (2004)
  Sparse graphical gaussian modeling for genetic regulatory network inference
  Genome Biology, 5, R92.1-R92.13    [Link]
   
• Zimmermann P, Hirsch-Hoffmann M, Hennig L, Gruissem W (2004)
  GENEVESTIGATOR: Arabidopsis Microarray Database and Analysis Toolbox
  Plant Physiology, 136, 1, 2621-2632    [Link]
   
• Hennig, L., Gruissem, W., Grossniklaus, U., and Köhler, C. (2004)
  Transcriptional programs of early stages of plant reproduction.
  Plant Physiology , 135, 1765-1775    [Link]
   
• Baginsky S and Gruissem W. (2004)
  Chloroplast proteomics: potentials and challenges.
  J Exp Bot, 55, 1213-1220    [Link]
   
• Ebel C, Mariconti L and Gruissem W. (2004)
  Plant retinoblastoma homologues control nuclear proliferation in the female gametophyte
  Nature, 429, 776-780    [Link]
   
• Running M, Lavy M, Sternberg H, Galichet A, Gruissem W, Hake S, Ori N and Yalovsky S. (2004)
  Enlarged meristems and delayed growth in plp mutants result from lack of CAAX prenyltransferases.
  Proc Natl Acad Sci USA, 101, 7815-7820    [Link]
   
• Poletti S, Gruissem W and Sautter C. (2004)
  The nutritional fortification of cereals.
  Curr Opin Biotechnology , 15, 162-165    [Link]
   
• Jelesko JG, Carter K, Thompson W, Kinoshita Y and Gruissem W. (2004)
  Meiotic recombination between paralogous RBCSB genes on sister chromatids of Arabdiopsis thaliana.
  Genetics , 166, 947-957    [Link]
   
• Kleffmann T, Russenberger D, von Zychlinsky A, Christopher W, Sjölander K, Gruissem W and Baginsky S. (2004)
  The Arabidopsis thaliana chloroplast proteome reveals pathway abundance and novel protein functions.
  Current Biology , 14, 354-362    [Link]
   
• Baginsky, S., Siddique, A. and Gruissem, W (2004)
  Proteome analysis of tobacco bright yellow-2 (BY-2) cell culture plastids as a model for undifferentiated heterotrophic plastids.
  Journal of Proteome Research, 3, 1128-1137
   
• Fischer, B., Roth, V., Buhmann, J., Grossmann, J., Baginsky, S., Gruissem, W., Roos, F. and Widmayer, P. (2004)
  A Hidden Markov Model for de Novo Peptide Sequencing
  NIPS, in press
   
• Stenger, D, Gruissem, W and Baginsky, S. (2004)
  Mass spectrometric identification of RNA-binding proteins from dried EMSA gels
  Journal of Proteome Research, 3, 662-664
   
• Zhang P and Gruissem W (2004)
  Production of transgenic cassava (Manihot esculenta Crantz)
  In: Transgenic Crops of the World - Essential Protocols, , Chapter 23, 301-319    [Link]
   
• Galichet, A and Gruissem, W (2003)
  Protein farnesylation in plants. Conserved mechanisms but different targets
  Current opinion in plant biology 6, 1-6, None, None    [Link]
   
• Zhang P, Bohl-Zenger S, Puonti-Kaerlas J, Potrykus I and Gruissem W (2003)
  Two cassava promoters related to vascular expression and storage root formation.
  Planta 218, 192-203    [Link]
   
• Bellaoui M, Keddie JS and Gruissem W. (2003)
  DCL is a plant-specific protein required for plastid ribosomal RNA processing and embryo development.
  Plant Mol Biol , 53, 531-543    [Link]
   
• Hennig L, Menges M, Murray JAH, Gruissem W (2003)
  Arabidopsis transcript profiling on Affymetrix GeneChip arrays.
  Plant Mol. Biol, 53, 457-465    [Link]
   
• Menges M, Hennig L, Gruissem W, Murray JAH (2003)
  Genome-wide gene expression in an Arabidopsis cell suspension.
  Plant Mol. Biol, 53, 423-442    [Link]
   
• Favaro, R., Pinyopich, A., Battaglia, R., Kooiker, M., Borghi, L., Ditta, G., Yanofsky, M.F., Kater, M.M., and Colombo, L. (2003)
  MADS-box protein complexes control carpel and ovule development in Arabidopsis.
  Plant Cell
   
• Köhler C., Hennig L., Bouveret R., Gheyselinck J., Grossniklaus U. and Gruissem W. (2003)
  Arabidopsis MSI1 is a component of the MEA/FIE Polycomb group complex and required for seed development
  EMBO J, 22, 4804-4814    [Link]
   
• Köhler, C., Hennig, L., Spillane, C., Pien, S., Gruissem, W., and Grossniklaus, U. (2003)
  The Polycomb-group protein MEDEA regulates seed development by controlling expression of the MADS-box gene PHERES1
  Genes & Development, 17, 1540-1553    [Link]
   
• Laule, O., Fürholz, A., Chang, H.S., Zhu, T., Wang, X., Heifetz, P.B., Gruissem, W., and Lange, B.M. (2003)
  Crosstalk between cytosolic and plastidial pathways of isoprenoid biosynthesis in Arabidopsis thaliana
  Proc Natl Acad Sci USA 100, 6866-6871, None, None    [Link]
   
• Hennig, L., Taranto, P., Walser, M., Schönrock, N., and Gruissem, W. (2003)
  Arabidopsis MSI1 is required for epigenetic maintenance of reproductive development.
  Development, 130, 2555-65    [Link]
   
• Zhang P and Gruissem W (2003)
  Efficient replication of cloned African cassava mosaic virus in cassava leaf disks.
  Virus Research 92, 47-54    [Link]
   
• Zhang P, Fütterer J, Frey P, Potrykus I, Puonti-Kaerlas J and Gruissem W (2003)
  Engineering virus-induced ACMV resistance by mimicking a hypersensitive reaction in transgenic cassava plants.
  In: Vasil I.K. (ed.) Plant Biotechnology 2002 and Beyond, 143-146    [Link]
   
• Zhang P, Jaynes JM, Potrykus I, Gruissem W and Puonti-Kaerlas J (2003)
  Transfer and expression of an artificial storage protein (ASP1) gene in cassava (Manihot esculenta Crantz).
  Transgenic Research, 12, 243-250    [Link]
   
• Baginsky, S. and Gruissem, W. (2002)
  Endonucleolytic activation directs dark-induced chloroplast mRNA degradation.
  Nucleic Acids Research 15, 4527-4533, None, None    [Link]
   
• Gruissem, W (2002)
  The cell cycle - now in plants
  Trends Plant Sci 7, 49, None, None    [Link]
   
• Luan, S., Kudla, J., Rodriguez-Conception, M., Yalowsky, S., and Gruissem, W. (2002)
  Calmodulins and calcineurin B-like proteins: calcium sensors for specific signal response coupling in plants
  Plant Cell 14 Suppl:S389-400, None, None    [Link]
   
• Menges, M., Hennig, L., Gruissem, W., and Murray, J. A. H. (2002)
  Cell cycle regulated gene expression in Arabidopsis.
  Journal of Biological Chemistry 277, 41987-42002, None, None    [Link]
   
• Reyes, J.C., Hennig, L. and Gruissem, W. (2002)
  Chromatin remodeling and memory factors—new regulators of plant development.
  Plant Physiology 130, 1090-1101, None, None    [Link]
   
• Baginsky S and Gruissem W. (2001)
  The chloroplast mRNA 3'-end nuclease complex.
  Methods Enzymology 342, 408-419 , None, None    [Link]
   
• Baginsky S, Shteiman-Kotler A, Livearu V, Yehudai-Resheff S, Bellaoui M, Settlage RE, Shabanowitz J, Hunt DF, Schuster G and Gruissem W. (2001)
  Chloroplast PNPase exists as a homo-multimer complex that is distinct from the E.coli degradosome.
  RNA 7, 1464-1475, None, None    [Link]
   
• Berdy SE, Kudla J, Gruissem W and Gillaspy G. (2001)
  Molecular characterization of At5PTase1, an inositol phosphatase capable of terminating inositol trisphosphate signaling.
  Plant Physiology 126: 801-810, None, None    [Link]
   
• Caldelari D, Sternberg H, Rodríguez-Concepción M, Gruissem W and Yalovsky S. (2001)
  Efficient prenylation by a plant geranylgeranyltransferase I requires a functional CaaL box motif and a proximal polybasic domain.
  Plant Physiology 126: 1416-1429, None, None    [Link]
   
• Gillaspy G and Gruissem W. (2001)
  Li+ induces hypertrophy and down-regulation of myo-inositol monophosphatase in tomato.
  Journal of Plant Growth Regulation 20: 78-86, None, None    [Link]
   
• Luan, S., Kudla, J., Harter, K., Gruissem, W., and Chory, J. (2001)
  Renaming genes and duplication of gene names in the literature
  Plant Cell 13, 2391-2392, None, None    [Link]
   
• Settlage SB, Miller AB, Gruissem W and Hanley-Bowdoin L. (2001)
  Dual interaction of a geminivirus replication accessory factor with a viral replication protein and a plant cell cycle regulator.
  Virology 279: 570-576., None, None    [Link]
   
• Durfee T, Feiler H and Gruissem W. (2000)
  Retinoblastoma-related proteins in plants: homologs or orthologs of their metazoan counteparts?
  Plant Mol Biol 43: 635-642, None, None    [Link]
   
• Kong LJ, Orozco BM, Roe JL, Nagar S, Ou S, Feiler HS, Durfee T, Miller AB, Gruissem W, Robertson D and Hanley-Bowdoin L. (2000)
  A geminivirus replication protein interacts with the plant Retinoblastoma protein through a novel domain to determine symptoms and tissue specificity of infection.
  EMBO Journal 19: 3485-3491, None, None    [Link]
   
• Rodríguez-Concepción M, Toledo-Ortiz, G, Yalovsky S, Caldelari D and Gruissem W. (2000)
  Carboxyl methylation of prenylated calmodulin CaM53 is required for efficient plasma membrane targeting of the protein.
  Plant Journal 24: 775-784, None, None    [Link]
   
• Yalovsky S, Kulukian A, Rodríguez-Concepción M, Young CA and Gruissem W. (2000)
  Functional requirement of plant farnesyltransferase during development of Arabidopsis.
  The Plant Cell 12: 1267-1278, None, None    [Link]
   
• Yalovsky S, Rodríguez-Concepción M, Bracha K, Toledo-Ortiz G and Gruissem W. (2000)
  Prenylation of the floral transcription factor APETALA1 modulates its function.
  The Plant Cell 12: 1257-1266, None, None    [Link]
   
• Jelesko J, Harper R, Furuya M and Gruissem W. (1999)
  Rare germinal unequal crossing-over leading to recombinant gene formation and gene duplication in Arabidopsis thaliana.
  Proc Natl Acad Sci USA, 96: 10302-10307, None, None    [Link]
   
• Jelesko J, Jenkins S, Rodríguez-Concepción M and Gruissem W. (1999)
  Regulation of tomato HMG1 during cell proliferation and growth.
  Planta 208: 310-318, None, None    [Link]
   
• Kudla J, Xu Q, Harter H, Gruissem W and Luan S. (1999)
  Genes for calcineurin B-like proteins in Arabidopsis are differentially regulated by stress signals.
  Proc Natl Acad Sci USA 96: 4718-4723, None, None    [Link]
   
• Rodríguez-Concepción M, Yalovsky S, Zik M, Fromm H and Gruissem W. (1999)
  The prenylation status of a novel plant calmodulin directs plasma membrane or nuclear localization of the protein.
  EMBO Journal 18: 1996-2007, None, None    [Link]
   
• Rodríguez-Concepción M. and Gruissem W. (1999)
  Arachidonic acid alters tomato HMG Expression and fruit growth and induces 3-hydroxy-3-methylglutary coen-zyme A reductase-independent lycopene accumulation.
  Plant Physiology 119: 41-48, None, None    [Link]
   
• Yalovsky S, Rodríguez-Concepción M and Gruissem W. (1999)
  Lipid modifications of proteins—slipping in and out of membranes.
  Trends Plant Sci 4: 439-445, None, None    [Link]
   
• Hayes R, Kudla J and Gruissem W. (1998)
  Degrading chloroplast mRNA: a new role for polyadenylation.
  Trends in Biochemical Sciences 24: 199-202, None, None    [Link]
   
• Keddie JS, Carroll BJ, Thomas CM, Reyes MEC, Klimyuk V, Holtan H, Gruissem W and Jones JDG (1998)
  Transposon tagging of the defective embryo and meristem gene of tomato.
  The Plant Cell 10: 877-887, None, None    [Link]
   
• Rodríguez-Concepción M, Yalovsky S and Gruissem W. (1998)
  Protein prenylation in plants: old friends and new targets.
  Plant Mol Biol 39: 865-870., None, None    [Link]
   
• Ach RA, Durfee T, Miller AB, Taranto P, Hanley-Bowdoin L, Zambryski PC and Gruissem W. (1997)
  RRB 1 and RRB2 encode maize Retinoblastoma-related proteins that interact with a plant D-type cyclin and geminivirus replication protein.
  Mol Cell Biol 17: 5077-5086., None, None    [Link]
   
• Ach RA, Taranto P and Gruissem W. (1997)
  A conserved family of WD-40 proteins bind to the Retinoblastoma protein in both plants and animals.
  The Plant Cell 9: 1595-1606., None, None    [Link]
   
• Yalovsky S, Trueblood CE, Callan KL, Narita JO, Jenkins SM, Rine J and Gruissem W. (1997)
  Plant farnesyltransferase can restore yeast Ras signaling and mating.
  Mol Cell Biol 17: 1986-1994., None, None    [Link]
   
• Abrahamson S and Gruissem W. (1996)
  Transcriptional and post-transcriptional gene regulation in plastids.
  Molecular Genetics of Photosynthesis - Frontiers of Molecular Biology, Andersson B, Salter AH and Barber J, eds, Oxford University Press, Oxford, pp 104-122., None, None
   
• Fleming AJ, Manzara T, Gruissem W and Kuhlemeier C. (1996)
  Fluorescent imaging of GUS activity and RT-PCR analysis of gene expression in the shoot apical meristem.
  Plant Journal 10: 745-754., None, None    [Link]
   
• Hayes R, Kudla J, Schuster G, Gabay L, Maliga P and Gruissem W. (1996)
  Chloroplast mRNA 3 end processing by a PNP/RNAse E-like Complex is regulated by nuclear-encoded RNA-binding proteins.
  EMBO Journal 15: 1132-1141., None, None    [Link]
   
• Keddie J, Carroll B, Jones JDG and W. Gruissem. (1996)
  The DCL gene of tomato is required for chloroplast development and palisade cell morphogenesis in leaves.
  EMBO Journal 15: 4208-4217. , None, None    [Link]
   
• Kudla J, Hayes R and Gruissem W. (1996)
  Polyadenylation accelerates degradation of chloroplast mRNA.
  EMBO Journal 15: 7137-7146., None, None    [Link]
   
• Lorraine E, Yalovsky S, Fabry S and Gruissem W. (1996)
  Tomato Rab1A homologs as tools for studying Rab geranylgeranyl transferase in plant cells.
  Plant Physiol., 110: 1337-1347., None, None    [Link]
   
• Luan S, Kudla J, Gruissem W and Schreiber SL. (1996)
  Molecular characterization of a FKBP-type immunophilin from higher plants.
  Proc Natl Acad Sci USA 93: 6964-6969, None, None    [Link]
   
• Luong JT, Gruissem W and Gillaspy G. (1996)
  Tomato inositol monophos-phatase: strcuture and function.
  Berkeley Scientific 1: 49-52. , None, None
   
• Meier I, Phelan T, Gruissem W, Spiker S and Schneider D. (1996)
  MFP1, a novel plant filament-like protein with affinity for matrix attachment region DNA.
  The Plant Cell 8: 2105-2115. , None, None    [Link]
   
• Roell M and Gruissem W. (1996)
  Chloroplast gene expression: Regulation at multiple levels.
  Advances in Photosynthesis, Oxygenic Photosynthesis: The Light Reactions, Ort DR and YocumCF, eds, Kluwer Academic Publishers, Dordrecht, pp 565-587., None, None
   
• Schmitt D, Callan K and Gruissem W. (1996)
  Molecular and biochemical characterization of tomato farnesyl-protein transferase.
  Plant Physiol 112: 767-777. , None, None    [Link]
   
• Yalovsky S, Lorraine AE and Gruissem W. (1996)
  Specific prenylation of tomato Rab proteins by geranylgernaly type-II transferase requires a conserved C-C motif.
  Plant Physiol., 110: 1349-1359., None, None
   
• Carrasco P and Gruissem W. (1995)
  In vivo genomic footprinting by ligation-mediated PCR. In Methods in Plant Molecular Biology
  A Laboratory Course, Maliga P, Klessig DF, Cashmore A, Gruissem W and Varner J, eds, Cold Spring Harbor Laboratory Press, pp. 349-378. , None, None
   
• Deng XW and Gruissem W. (1995)
  Chloroplast run-on transcription: Determination of the transcriptional activity of chloroplast genes.
  In Methods in Plant Molecular Biology: A Laboratory Course, Maliga P, Klessig DF, Cashmore A, Gruissem W and Varner J, eds, Cold Spring Harbor Laboratory Press, pp. 191-208. , None, None
   
• Gillaspy GE, Keddie JS, Oda K and Gruissem W. (1995)
  Plant inositol monophosphatase is a lithium-sensitive enzyme encoded by a multigene family.
  The Plant Cell 7: 2175-2185., None, None    [Link]
   
• Klaff P and Gruissem W. (1995)
  Identification of a 43 Kd light-regulated chloroplast RNA-binding protein that interacts with the psbA 5 non-translated leader RNA.
  Photosynth. Res. 46: 235-248. , None, None
   
• Maliga P, Klessig DF, Cashmore A, Gruissem W and Varner J. (1995)
  Methods in Plant Molecular Biology
  A Laboratory Course, Cold Spring Harbor Laboratory Press, New York. , None, None
   
• Manzara T and Gruissem W. (1995)
  Identification of promoter sequences that interact with DNA-binding proteins.
  In Methods in Plant Molecular Biology: A Laboratory Course, Maliga P, Klessig DF, Cashmore A, Gruissem W and Varner J, eds, Cold Spring Harbor Laboratory Press, pp. 233-260. , None, None
   
• Meier I, Callan K, Fleming AJ, Manzara T and Gruissem W. (1995)
  Organ-specific differential regulation of a RBCS promoter subfamily in tomato.
  Plant Physiol., 107: 1105-1118. , None, None    [Link]
   
• Schuster G and Gruissem W. (1995)
  In vitro processing of RNA and analysis of RNA-protein interactions by UV-crosslinking.
  In Methods in Plant Molecular Biology: A Laboratory Course, Maliga P, Klessig DF, Cashmore A, Gruissem W and Varner J, eds, Cold Spring Harbor Laboratory Press, pp. 209-232. , None, None
   
• Ach RA and Gruissem W. (1994)
  A small GTP-binding protein from tomato suppresses a Schizosacharomyces pombe cell cycle mutant.
  Proc Natl Acad Sci USA 91: 5863-5867., None, None    [Link]
   
• Gruissem W. (1994)
  Regulation of plastid gene expression.
  In Plant Molecular Biology: Molecular-Genetic Analysis of Plant Development, Coruzzi G and Puigdomenech P, eds. NATO H81, Springer Verlag, New York, p. 361-370., None, None
   
• Meier I and Gruissem W (1994)
  Conserved sequence motifs in plant G-box binding proteins and implications for interactive domains.
  Nucleic Acids Res 22: 470-478., None, None    [Link]
   
• Carrasco P, Manzara T, and Gruissem W (1993)
  Developmental and organ-specific DNA-protein interactions in the promoter regions of the linked locus 3 genes in tomato.
  Plant Mol. Biol. 21: 1-15., None, None    [Link]
   
• Gillaspy G, Ben-David H and Gruissem W. (1993)
  Fruits: A developmental perspective.
  Plant Cell 5: 1439-1451. , None, None
   
• Gillaspy G, Narita JO, Dean S, Loraine A, Schmitt D and Gruissem W. (1993)
  The role of HMG CoA reductase in tomato fruit development.
  In Molecular Biology of Tomato, Yoder J, ed. Technomic Publishing Co, Basel, pp 107-118. , None, None
   
• Gruissem W and Schuster G (1993)
  Control of mRNA degradation in organelles.
  In Control of mRNA stability, Belasco J and Brawerman G, eds, Academic Press, pp. 329-365., None, None
   
• Gruissem W and Tonkyn J (1993)
  Control mechanisms of plastid gene expression.
  CRC Critical Rev Plant Biol 12: 19-55., None, None
   
• Hell R, Schuster G and Gruissem W. (1993)
  An O-acetylserine (thiol) lyase cDBA from spinach.
  Plant Physiol 102: 1057-1058., None, None    [Link]
   
• Manzara T, Carrasco P and Gruissem W (1993)
  Developmental and organ-specific changes in promoter DNA-protein interactions in the tomato rbcS1, rbcS2 abd rbcS3A promoter regions.
  Plant Mol. Biol. 21: 69-88., None, None    [Link]
   
• Tonkyn J and Gruissem W (1993)
  Differential expression of the partially duplicated chloroplast S10 ribosomal protein operon.
  Mol Gen Genet 241: 141-152., None, None    [Link]
   
• Tonkyn, JC, Deng XW and Gruissem W (1992)
  Regulation of plastid gene expression during photooxidative stress.
  Plant Phys, 99: 1406-1415. , None, None
   
• Bach TJ, Wettstein A, Boronat A, Ferrer A, Enjuto M, Narita JO, Gruissem W. (1991)
  Properties and molecular cloning of plant HMG-CoA reductase.
  In: Physiology and Biochemistry of Sterols., Patterson GW and Nes WD, eds, Amer Oil Chem Soc, Illinois, pp 29-49. , None, None
   
• Narita J and Gruissem W. (1989)
  Tomato hydroxymethylglutaryl-CoA reductase is required early in fruit development but not during ripening.
  Plant Cell 1: 181-190. , None, None    [Link]